In 1932 the twins appeared as themselves in the movie Freaks, which dared to pose the question of whether or not conjoined twins can have a love life. In the case of the Hilton sisters, the answer was yes - they were notorious for their many affairs and allegedly had a strong desire to outdo one another in the area of dating. Because the sisters shared sensations, as suggested by the film, they developed an ability to "separate" themselves from one another mentally. Daisy also dyed her hair blonde because she disliked being called by her sister's name. Each of the sisters was married separately, although they bore no children and each marriage lasted only a short time.
After the public lost interest in Siamese twins, the sisters settled in Miami and ran a hamburger stand called the Hilton Sisters' Snack Bar. When the business failed, they turned to Hollywood. In 1950 the sisters appeared in the film Chained for Life, which, despite its poor production values, does a grand job of showcasing the Hilton sisters' voices. When Freaks was re-released to a cult audience in the 1960s, the sisters went on a national publicity tour.
Their last public appearance was in North Carolina at a drive-in movie theatre. The man who had set up the tour date had promised to pick them up following the appearance, but failed to show up. Penniless and stranded, they were forced to take a job at a grocery store, with one working the register and the other bagging groceries. On January 6, 1969, the twins failed to report for work and were later found dead in their home, from the Hong Kong flu.